What are the Brightly Baseline+™ biomarkers?
Brightly Baseline+™ biomarkers are the 100+ measurable data points we use to understand how well you are ageing today and where future risks may be emerging.
What are the Brightly Baseline+™ biomarkers?
Brightly Baseline+™ biomarkers are the 100+ measurable data points we use to understand how well you are ageing today and where future risks may be emerging.

They are drawn from your health history and questionnaire responses, physical assessments and performance measures, and clinical investigations including blood tests.
Together, they provide an objective, evidence informed picture of your health across physical health, cognition, mobility, nutrition, sleep, medication, and more. Your assessment is personalised to your health profile, with biomarkers included where clinically applicable. By analysing these indicators together, we identify risk early and track progress over time, supporting confident and proactive ageing.
Click the health domains below to see the specific biomarkers we assess, what they measure and why they matter.
Strength, Mobility & Balance
Biomarker |
What it measures |
Why it matters |
What this may help prevent |
|
Grip strength (dynamometer) |
Muscle strength reserve |
Strong predictor of frailty and mortality |
Falls, disability, hospital admissions, early need for rest home care |
|
Standing balance (4-stage test) |
Postural stability |
Balance decline precedes falls |
Falls, low impact (osteoporotic) fractures, emergency presentations, loss of confidence |
|
Vitamin D (blood) |
Bone and neuromuscular function |
Deficiency increases weakness and falls |
Fractures, falls, hospital admissions |
Bone Health & Falls Risk
Biomarker |
What it measures |
Why it matters |
What this may help prevent |
|
Falls history (past 12 months) |
Falls frequency and circumstances |
A previous fall strongly predicts future falls and injury |
Recurrent falls, fractures, hospital admissions |
|
Chair rise test (standing without hands) |
Functional lower limb strength |
Difficulty rising is linked to higher fall, fracture and frailty risk |
Mobility loss, increasing dependence, early residential care |
|
Osteoporosis risk profile (risk factors and history) |
Clinical fracture risk (e.g., prior fracture, steroid exposure, family history) |
Hip and spine fractures are major drivers of disability in later life |
Fragility fractures, long-term disability, residential care entry |
|
Vitamin D (blood test) |
Bone and muscle support |
Deficiency increases falls and fracture risk |
Fragility fractures, recurrent falls |
|
Serum calcium (blood test) |
Calcium balance |
Abnormal levels may signal metabolic contributors to bone weakness |
Bone weakness, fracture risk |
Mind Health (Cognition & Memory)
Biomarker |
What it measures |
Why it matters |
What this may help prevent |
|
Mini-Addenbrooke’s Cognitive Examination (Mini-ACE) score |
Cognitive performance across memory, attention, fluency and visuospatial skills |
Early cognitive changes may impact independence and daily function |
Medication errors, unsafe driving, financial vulnerability, avoidable hospital admissions and delirium during acute illness or hospital admission |
|
Functional cognition questions (impact on hobbies, daily tasks, family feedback) |
Real-world cognition and day-to-day functioning |
Functional decline often appears before formal diagnosis |
Safety risks at home, financial vulnerability |
|
Vitamin B12 (blood test) |
Nerve and brain health |
Low B12 can mimic cognitive decline and cause neuropathy |
Reversible confusion, falls from neuropathy |
|
Thyroid stimulating hormone (TSH) (blood test) |
Thyroid balance affecting energy and cognition |
Thyroid dysfunction can present as memory issues |
Treatable cognitive symptoms |
|
Glycated haemoglobin (HbA1c) (blood test) |
Long-term blood sugar exposure |
Higher levels increase cardiovascular and cerebrovascular risk |
Stroke and vascular dementia |
Social Wellbeing
Biomarker |
What it measures |
Why it matters |
What this may help prevent |
|
Social connection frequency (contact pattern) |
How often a person connects with others |
Isolation is linked to poorer health outcomes and faster decline |
Depression, accelerated cognitive decline, avoidable admissions |
|
Loneliness Indicator |
How lonely a person feels regardless of contacts |
Loneliness is a strong predictor of decline |
Depression, functional decline, early residential care |
|
Purpose and Quality of Life Indicator |
Overall wellbeing trajectory |
Purpose and wellbeing correlate with resilience and health behaviours |
Loss of motivation, reduced activity, decline |
Sleep
Biomarker |
What it measures |
Why it matters |
What this may help prevent |
|
Sleep quality |
Difficulty falling or staying asleep |
Poor sleep and sedative medications increase falls risk, mood symptoms and cognitive strain |
Falls, hospital admissions, daytime impairment |
|
Daytime sleepiness |
Daytime alertness and fatigue |
Daytime sleepiness affects driving and safety |
Accidents, falls, reduced function |
Nutrition & Diet
Biomarker |
What it measures |
Why it matters |
What this may help prevent |
|
Nutritional Assessment |
Malnutrition risk |
Malnutrition increases frailty, infection risk and poor recovery |
Hospital admissions, infections, early residential care |
|
Body mass index (BMI) |
Body size relative to height |
Both low BMI and high BMI increase health risk in ageing |
Frailty, diabetes, heart disease |
|
Recent weight loss / reduced intake |
Catabolic risk and appetite change |
Unintentional weight loss can signal illness and increases frailty risk |
Frailty progression, hospital admissions |
|
Serum albumin (blood test) |
Protein reserve and illness burden and liver synthetic function |
Low levels predict poorer recovery and resilience |
Hospitalisation risk, delayed recovery |
|
Iron studies (blood test: ferritin, transferrin saturation and iron) |
Iron stores and availability |
Low iron status contributes to fatigue, weakness and reduced exercise tolerance |
Falls risk, functional decline |
|
Folate (blood test) |
Nutrient supporting red blood cells and brain |
Low folate can contribute to fatigue and cognitive symptoms |
Functional decline |
|
Vitamin B12 (blood test) |
Nerve and brain health |
Deficiency can cause neuropathy and cognitive symptoms |
Falls (via neuropathy), cognitive impairment |
Hearing, Vision & Oral Health
Biomarker |
What it measures |
Why it matters |
What this may help prevent |
|
Hearing difficulty |
Hearing function in daily life |
Hearing loss is linked to isolation and cognitive strain |
Depression, cognitive decline, safety issues |
|
Snellen visual acuity test |
Distance vision clarity |
Vision loss increases falls and driving risk |
Falls, driving accidents |
|
Functional vision questions |
Everyday vision capability |
Functional impairment predicts medication and safety errors |
Medication errors, falls |
|
Oral health status (pain, dentures fit, last dental visit) |
Oral comfort, chewing and dental care access |
Oral health affects nutrition and infection risk |
Weight loss, infections, poor nutrition |
Medication Optimisation & Safety
Biomarker |
What it measures |
Why it matters |
What this may help prevent |
|
Polypharmacy count (regular medicines) |
Medication burden |
Higher medication burden increases side effects and interactions |
Falls, delirium, avoidable hospital admissions |
|
High-risk medication exposure (e.g., sedatives, strong pain medicines) |
Medication-related harm risk |
Certain medicines increase falls, confusion and bleeding risk |
Falls, delirium, admissions to hospital and residential care |
|
Adherence and medication system reliability |
Ability to take medicines correctly |
Missed doses or double dosing can cause harm or deterioration |
Avoidable admissions, treatment failure |
|
Glomerular Filtration Rate (GFR) (blood test) |
Kidney filtration for safe dosing |
Kidney function changes with age and affects medication safety |
Drug toxicity, hospital admissions |
|
Creatinine (blood test) |
Kidney function marker used to calculate eGFR |
Supports safe prescribing |
Drug toxicity |
|
Liver function tests (ALT, AST, GGT, Albumin) (blood test) |
Liver enzymes and synthetic function |
Liver function influences medication metabolism and overall health |
Medication-related harm, broader health risk |
Cardiovascular & Respiratory Health
Biomarker |
What it measures |
Why it matters |
What this may help prevent |
|
Blood pressure (lying and standing) |
Blood pressure control and postural drop |
Major driver of stroke and dizziness-related falls |
Stroke, fainting (syncope), hospital admissions |
|
Pulse rate and rhythm check |
Heart rate and rhythm regularity |
Irregular rhythm can indicate atrial fibrillation (AF) |
Stroke, heart failure exacerbations |
|
Glycated haemoglobin (HbA1c) (blood test) |
Long-term glucose exposure |
Higher levels accelerate vascular ageing |
Diabetes complications, vascular events |
|
Total cholesterol (blood test) |
Overall cholesterol level |
High levels contribute to plaque build-up |
Heart attack, stroke |
|
Low-density lipoprotein cholesterol (LDL) (blood test) |
“Bad” cholesterol |
Key driver of atherosclerosis |
Heart attack, stroke |
|
High-density lipoprotein cholesterol (HDL) (blood test) |
“Good” cholesterol |
Low levels associated with higher risk |
Vascular events |
|
Triglycerides (blood test) |
Blood fat linked to insulin resistance |
Elevated levels increase cardiometabolic risk |
Vascular events |
Bowel Health
Biomarker |
What it measures |
Why it matters |
What this may help prevent |
|
Bowel function pattern (frequency, stool form, straining) |
Constipation/diarrhoea pattern and severity |
Bowel issues impact comfort, appetite, sleep and function, urinary function. |
Delirium from constipation, avoidable hospital admissions, bladder dysfunction |
|
Blood in stool or change in bowel habit (red flags) |
Warning symptoms for bowel disease |
Early identification improves outcomes |
Advanced bowel disease, delayed diagnosis |
|
Faecal incontinence frequency and impact |
Bowel control and quality-of-life impact |
Major driver of social withdrawal and care needs |
Loss of independence, early residential care |
Urinary Health
Biomarker |
What it measures |
Why it matters |
What this may help prevent |
|
Urinary symptoms (women: leakage frequency/type and bother) |
Bladder control and symptom impact |
Incontinence increases falls risk and social withdrawal |
Falls, sleep disruption, depression |
|
Urinary symptoms (men: lower urinary tract symptoms and nocturia) |
Flow and night-time urination burden |
Nocturia contributes to falls and daytime fatigue |
Falls, functional decline related to poor sleep |
|
Pad use (24 hours) |
Practical severity marker |
Helps quantify impact and need for support |
Skin irritation, social withdrawal |
Pain (Arthritis)
Biomarker |
What it measures |
Why it matters |
What this may help prevent |
|
Pain severity and impact assessment |
Pain burden and functional limitation |
Persistent pain drives inactivity, frailty and mood decline |
Mobility loss, falls, avoidable admissions |
|
Morning stiffness duration and pattern |
Inflammatory vs mechanical pain signals |
Inflammatory arthritis needs early identification to prevent joint damage |
Progressive joint damage, disability |
Safe Driving
Biomarker |
What it measures |
Why it matters |
What this may help prevent |
|
Driving exposure and pattern (how often, where, day/night) |
Driving frequency and complexity |
Higher exposure increases risk if function declines |
Accidents, injury, loss of licence crisis |
|
Driving concerns (self and family) and near-misses |
Perceived safety and recent warning signs |
Concerns often precede incidents |
Accidents, injury-related admissions |
Home & Environmental Safety
Biomarker |
What it measures |
Why it matters |
What this may help prevent |
|
Home safety |
Environmental fall and safety hazards |
Home hazards are a common, modifiable contributor to falls |
Falls, fractures, hospital admissions |
Strength, Mobility & Balance
Grip strength (dynamometer)
- What it measures: Muscle strength reserve
- Why it matters: Strong predictor of frailty and mortality
- What this may help prevent: Falls, disability, hospital admissions, early need for rest home care
Standing balance (4-stage test)
- What it measures: Postural stability
- Why it matters: Balance decline precedes falls
- What this may help prevent: Falls, low impact (osteoporotic) fractures, emergency presentations, loss of confidence
Vitamin D (blood)
- What it measures: Bone and neuromuscular function
- Why it matters: Deficiency increases weakness and falls
- What this may help prevent: Fractures, falls, hospital admissions
Bone Health & Falls Risk
Falls history (past 12 months)
- What it measures: Falls frequency and circumstances
- Why it matters: A previous fall strongly predicts future falls and injury
- What this may help prevent: Recurrent falls, fractures, hospital admissions
Chair rise test (standing without hands)
- What it measures: Functional lower limb strength
- Why it matters: Difficulty rising is linked to higher fall, fracture and frailty risk
- What this may help prevent: Mobility loss, increasing dependence, early residential care
Osteoporosis risk profile (risk factors and history)
- What it measures: Clinical fracture risk (e.g., prior fracture, steroid exposure, family history)
- Why it matters: Hip and spine fractures are major drivers of disability in later life
- What this may help prevent: Fragility fractures, long-term disability, residential care entry
Vitamin D (blood test)
- What it measures: Bone and muscle support
- Why it matters: Deficiency increases falls and fracture risk
- What this may help prevent: Fragility fractures, recurrent falls
Serum calcium (blood test)
- What it measures: Calcium balance
- Why it matters: Abnormal levels may signal metabolic contributors to bone weakness
- What this may help prevent: Bone weakness, fracture risk
Mind Health (Cognition & Memory)
Mini-Addenbrooke’s Cognitive Examination (Mini-ACE) score
- What it measures: Cognitive performance across memory, attention, fluency and visuospatial skills
- Why it matters: Early cognitive changes may impact independence and daily function
- What this may help prevent: Medication errors, unsafe driving, financial vulnerability, avoidable hospital admissions and delirium during acute illness or hospital admission
Functional cognition questions (impact on hobbies, daily tasks, family feedback)
- What it measures: Real-world cognition and day-to-day functioning
- Why it matters: Functional decline often appears before formal diagnosis
- What this may help prevent: Safety risks at home, financial vulnerability
Vitamin B12 (blood test)
- What it measures: Nerve and brain health
- Why it matters: Low B12 can mimic cognitive decline and cause neuropathy
- What this may help prevent: Reversible confusion, falls from neuropathy
Thyroid stimulating hormone (TSH) (blood test)
- What it measures: Thyroid balance affecting energy and cognition
- Why it matters: Thyroid dysfunction can present as memory issues
- What this may help prevent: Treatable cognitive symptoms
Glycated haemoglobin (HbA1c) (blood test)
- What it measures: Long-term blood sugar exposure
- Why it matters: Higher levels increase cardiovascular and cerebrovascular risk
- What this may help prevent: Stroke and vascular dementia
Social Wellbeing
Social connection frequency (contact pattern)
- What it measures: How often a person connects with others
- Why it matters: Isolation is linked to poorer health outcomes and faster decline
- What this may help prevent: Depression, accelerated cognitive decline, avoidable admissions
Loneliness Indicator
- What it measures: How lonely a person feels regardless of contacts
- Why it matters: Loneliness is a strong predictor of decline
- What this may help prevent: Depression, functional decline, early residential care
Purpose and Quality of Life Indicator
- What it measures: Overall wellbeing trajectory
- Why it matters: Purpose and wellbeing correlate with resilience and health behaviours
- What this may help prevent: Loss of motivation, reduced activity, decline
Sleep
Sleep quality
- What it measures: Difficulty falling or staying asleep
- Why it matters: Poor sleep and sedative medications increase falls risk, mood symptoms and cognitive strain
- What this may help prevent: Falls, hospital admissions, daytime impairment
Daytime sleepiness
- What it measures: Daytime alertness and fatigue
- Why it matters: Daytime sleepiness affects driving and safety
- What this may help prevent: Accidents, falls, reduced function
Nutrition & Diet
Nutritional Assessment
- What it measures: Malnutrition risk
- Why it matters: Malnutrition increases frailty, infection risk and poor recovery
- What this may help prevent: Hospital admissions, infections, early residential care
Body mass index (BMI)
- What it measures: Body size relative to height
- Why it matters: Both low BMI and high BMI increase health risk in ageing
- What this may help prevent: Frailty, diabetes, heart disease
Recent weight loss / reduced intake
- What it measures: Catabolic risk and appetite change
- Why it matters: Unintentional weight loss can signal illness and increases frailty risk
- What this may help prevent: Frailty progression, hospital admissions
Serum albumin (blood test)
- What it measures: Protein reserve and illness burden and liver synthetic function
- Why it matters: Low levels predict poorer recovery and resilience
- What this may help prevent: Hospitalisation risk, delayed recovery
Iron studies (blood test: ferritin, transferrin saturation and iron)
- What it measures: Iron stores and availability
- Why it matters: Low iron status contributes to fatigue, weakness and reduced exercise tolerance
- What this may help prevent: Falls risk, functional decline
Folate (blood test)
- What it measures: Nutrient supporting red blood cells and brain
- Why it matters: Low folate can contribute to fatigue and cognitive symptoms
- What this may help prevent: Functional decline
Vitamin B12 (blood test)
- What it measures: Nerve and brain health
- Why it matters: Deficiency can cause neuropathy and cognitive symptoms
- What this may help prevent: Falls (via neuropathy), cognitive impairment
Hearing, Vision & Oral Health
Hearing difficulty
- What it measures: Hearing function in daily life
- Why it matters: Hearing loss is linked to isolation and cognitive strain
- What this may help prevent: Depression, cognitive decline, safety issues
Snellen visual acuity test
- What it measures: Distance vision clarity
- Why it matters: Vision loss increases falls and driving risk
- What this may help prevent: Falls, driving accidents
Functional vision questions
- What it measures: Everyday vision capability
- Why it matters: Functional impairment predicts medication and safety errors
- What this may help prevent: Medication errors, falls
Oral health status (pain, dentures fit, last dental visit)
- What it measures: Oral comfort, chewing and dental care access
- Why it matters: Oral health affects nutrition and infection risk
- What this may help prevent: Weight loss, infections, poor nutrition
Medication Optimisation & Safety
Polypharmacy count (regular medicines)
- What it measures: Medication burden
- Why it matters: Higher medication burden increases side effects and interactions
- What this may help prevent: Falls, delirium, avoidable hospital admissions
High-risk medication exposure (e.g., sedatives, strong pain medicines)
- What it measures: Medication-related harm risk
- Why it matters: Certain medicines increase falls, confusion and bleeding risk
- What this may help prevent: Falls, delirium, admissions to hospital and residential care
Adherence and medication system reliability
- What it measures: Ability to take medicines correctly
- Why it matters: Missed doses or double dosing can cause harm or deterioration
- What this may help prevent: Avoidable admissions, treatment failure
Glomerular Filtration Rate (GFR) (blood test)
- What it measures: Kidney filtration for safe dosing
- Why it matters: Kidney function changes with age and affects medication safety
- What this may help prevent: Drug toxicity, hospital admissions
Creatinine (blood test)
- What it measures: Kidney function marker used to calculate eGFR
- Why it matters: Supports safe prescribing
- What this may help prevent: Drug toxicity
Liver function tests (ALT, AST, GGT, Albumin) (blood test)
- What it measures: Liver enzymes and synthetic function
- Why it matters: Liver function influences medication metabolism and overall health
- What this may help prevent: Medication-related harm, broader health risk
Cardiovascular & Respiratory Health
Blood pressure (lying and standing)
- What it measures: Blood pressure control and postural drop
- Why it matters: Major driver of stroke and dizziness-related falls
- What this may help prevent: Stroke, fainting (syncope), hospital admissions
Pulse rate and rhythm check
- What it measures: Heart rate and rhythm regularity
- Why it matters: Irregular rhythm can indicate atrial fibrillation (AF)
- What this may help prevent: Stroke, heart failure exacerbations
Glycated haemoglobin (HbA1c) (blood test)
- What it measures: Long-term glucose exposure
- Why it matters: Higher levels accelerate vascular ageing
- What this may help prevent: Diabetes complications, vascular events
Total cholesterol (blood test)
- What it measures: Overall cholesterol level
- Why it matters: High levels contribute to plaque build-up
- What this may help prevent: Heart attack, stroke
Low-density lipoprotein cholesterol (LDL) (blood test)
- What it measures: “Bad” cholesterol
- Why it matters: Key driver of atherosclerosis
- What this may help prevent: Heart attack, stroke
High-density lipoprotein cholesterol (HDL) (blood test)
- What it measures: “Good” cholesterol
- Why it matters: Low levels associated with higher risk
- What this may help prevent: Vascular events
Triglycerides (blood test)
- What it measures: Blood fat linked to insulin resistance
- Why it matters: Elevated levels increase cardiometabolic risk
- What this may help prevent: Vascular events
Bowel Health
Bowel function pattern (frequency, stool form, straining)
- What it measures: Constipation/diarrhoea pattern and severity
- Why it matters: Bowel issues impact comfort, appetite, sleep and function, urinary function.
- What this may help prevent: Delirium from constipation, avoidable hospital admissions, bladder dysfunction
Blood in stool or change in bowel habit (red flags)
- What it measures: Warning symptoms for bowel disease
- Why it matters: Early identification improves outcomes
- What this may help prevent: Advanced bowel disease, delayed diagnosis
Faecal incontinence frequency and impact
- What it measures: Bowel control and quality-of-life impact
- Why it matters: Major driver of social withdrawal and care needs
- What this may help prevent: Loss of independence, early residential care
Urinary Health
Urinary symptoms (women: leakage frequency/type and bother)
- What it measures: Bladder control and symptom impact
- Why it matters: Incontinence increases falls risk and social withdrawal
- What this may help prevent: Falls, sleep disruption, depression
Urinary symptoms (men: lower urinary tract symptoms and nocturia)
- What it measures: Flow and night-time urination burden
- Why it matters: Nocturia contributes to falls and daytime fatigue
- What this may help prevent: Falls, functional decline related to poor sleep
Pad use (24 hours)
- What it measures: Practical severity marker
- Why it matters: Helps quantify impact and need for support
- What this may help prevent: Skin irritation, social withdrawal
Pain (Arthritis)
Pain severity and impact assessment
- What it measures: Pain burden and functional limitation
- Why it matters: Persistent pain drives inactivity, frailty and mood decline
- What this may help prevent: Mobility loss, falls, avoidable admissions
Morning stiffness duration and pattern
- What it measures: Inflammatory vs mechanical pain signals
- Why it matters: Inflammatory arthritis needs early identification to prevent joint damage
- What this may help prevent: Progressive joint damage, disability
Safe Driving
Driving exposure and pattern (how often, where, day/night)
- What it measures: Driving frequency and complexity
- Why it matters: Higher exposure increases risk if function declines
- What this may help prevent: Accidents, injury, loss of licence crisis
Driving concerns (self and family) and near-misses
- What it measures: Perceived safety and recent warning signs
- Why it matters: Concerns often precede incidents
- What this may help prevent: Accidents, injury-related admissions
Home & Environmental Safety
Home safety
- What it measures: Environmental fall and safety hazards
- Why it matters: Home hazards are a common, modifiable contributor to falls
- What this may help prevent: Falls, fractures, hospital admissions
*These biomarker tables are general information. Results and recommendations are individual and depend on your circumstances, and we’ll discuss what’s appropriate for you after your assessment.
For people who want to live independently, confidently, and well.
Brightly is designed for those who:
- Want to be proactive about their health and longevity.
- Value independence and want to live in their own home for longer.
- Prefer preventative, evidence-based care over reactive treatment.
- Want coordinated support for physical, emotional, and social wellbeing.
Join the movement.
Whether you’re ready to book your first assessment or simply want to learn more, we’d love to hear from you. Brightly makes ageing well simple, empowering, and accessible.
Join the movement.
Whether you’re ready to book your first assessment or simply want to learn more, we’d love to hear from you. Brightly makes ageing well simple, empowering, and accessible.